Accession Number:

AD1031184

Title:

Discovery and Synthesis of GS-5734, a Phosphoramidate Prodrug of a Pyrrolo[2,1 f][triazin-4-amino] Adenine C-Nucleoside for the Treatment of Ebola and Emerging Viruses

Descriptive Note:

OSTP Journal Article

Corporate Author:

USAMRIID Frederick United States

Report Date:

2017-01-26

Pagination or Media Count:

59.0

Abstract:

The recent Ebola outbreak in West Africa was the largest recorded in history with over 28,000 cases confirmed in Guinea, Liberia, and Sierra Leone resulting in 11,000 deaths including 500 healthcare workers. This international crisis demonstrated the urgent need for a safe, effective and readily available treatment of Ebola infection. Multiple promising small molecule drugs and biologics were rapidly pushed into clinical trials, including several nucleoside based therapeutics.

Subject Categories:

  • Microbiology
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE