Acceleration of Regeneration of Large-Gap Peripheral Nerve Injuries Using Acellular Nerve Allografts plus amniotic Fluid Derived Stem Cells (AFS)
Technical Report,01 Sep 2015,31 Aug 2016
Wake Forest University Health Sciences Winston-Salem United States
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Major accomplishments this year include the use of AFS seeded a cellular Nerve Allografts ANA to repair critical size nerve defects 1.5cm in rats. Functional recovery was monitored longitudinally using digital video gait analysis as wells as electrophysiologic and histologic outcomes. The results demonstrated that the AFS seeded ANA used for nerve repair resulted in an improved functional outcome for the rats compared to ANA alone and were equivalent to those repaired using nerve autograph, the current gold standard for tension-free repair of transected peripheral nerves. Axon counts and neuromuscular junction morphology were equivalent between the AFS seeded ANA.
- Medicine and Medical Research
- Anatomy and Physiology