Accession Number:

AD1031113

Title:

Acceleration of Regeneration of Large-Gap Peripheral Nerve Injuries Using Acellular Nerve Allografts plus amniotic Fluid Derived Stem Cells (AFS)

Descriptive Note:

Technical Report,01 Sep 2015,31 Aug 2016

Corporate Author:

Wake Forest University Health Sciences Winston-Salem United States

Personal Author(s):

• Smith,Thomas L
• Zhongyu,Li

Report Date:

2016-09-01

Pagination or Media Count:

42.0

Abstract:

Major accomplishments this year include the use of AFS seeded a cellular Nerve Allografts ANA to repair critical size nerve defects 1.5cm in rats. Functional recovery was monitored longitudinally using digital video gait analysis as wells as electrophysiologic and histologic outcomes. The results demonstrated that the AFS seeded ANA used for nerve repair resulted in an improved functional outcome for the rats compared to ANA alone and were equivalent to those repaired using nerve autograph, the current gold standard for tension-free repair of transected peripheral nerves. Axon counts and neuromuscular junction morphology were equivalent between the AFS seeded ANA.

Descriptors:

• PERIPHERAL NERVOUS SYSTEM
• stem cells
• nerves

Subject Categories:

• Medicine and Medical Research
• Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE