Accession Number:

AD1031102

Title:

A Molecular Framework for Understanding DCIS

Descriptive Note:

Technical Report,30 Sep 2015,29 Oct 2016

Corporate Author:

University of Cambridge Cambridge United Kingdom

Personal Author(s):

• Hannon,Gregory
• Rebbeck,Clare

Report Date:

2016-10-01

Pagination or Media Count:

7.0

Abstract:

This project centers on creating a molecular framework of DCIS ductal carcinoma in situ. DCIS is considered to be the precursor to Invasive Ductal Carcinoma IDC, the most common form of breast cancer. IDC accounts for 80 of all breast cancers, predominantly affecting women aged 55 and older however, at least a third of women with IDC are diagnosed before they reach55. Not all patients with DCIS will develop IDC however, we are looking for ways to better predict those patients that need lifesaving treatment, and separate these from those patients who are less at risk. So far we have over 3000 lesions dissected from 70 freshly frozen patient biopsies, these have been annotated by our pathologist and prepared to be taken on for sequencing. The tissue includes DCIS, IDC, stroma adjacent to DCISIDC and normal tissue. We have initiated the RNA sequencing from these samples and also the DNA sequencing

Descriptors:

• carcinoma
• neoplasms
• breast cancer
• biomedical research
• molecular biology
• precursors
• therapeutics

Subject Categories:

• Genetic Engineering and Molecular Biology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE