Accession Number:

AD1031099

Title:

Regional Anesthesia and Valproate Sodium for the Prevention of Chronic Post Amputation Pain

Descriptive Note:

Technical Report,01 Oct 2015,29 Sep 2016

Corporate Author:

Duke University Durham United States

Personal Author(s):

• Buchheit,Thomas E.
• Van de Ven,Thomas
• Hsia,Hung-Lun (John)
• Buckenmaier,Chester

Report Date:

2016-10-01

Pagination or Media Count:

11.0

Abstract:

The purpose of this research is to determine if FDA approved Valproic Acid, commonly used for migraine headache prophylaxis, will also be effective in the prevention of chronic neuropathic pain. Additionally, this research will define the effect of pre-surgical methylation on the susceptibility to chronic pain, the effect of surgically induced methylation changes on the incidence of chronic pain, and the effect of valproic acid on DNA methylation status. Because this is a double-blinded, randomized controlled trial, we do not anticipate any major findings until the study is closed and the blinding removed. We are pleased to report that there have been no SAEs attributed to study drug, and that the study drug appears to be well tolerated at all three enrollment sites Walter Reed National Military Medical Center, Duke, and the Durham VA Medical Center especially at the Durham VAMC in a generally older, debilitated population.

Descriptors:

• pain
• clinical trials
• methylation
• amputation
• epigenetics
• pain management
• therapeutics
• anesthesia

Subject Categories:

• Medicine and Medical Research
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE