Role of Activin A in Immune Response to Breast Cancer
Technical Report,15 Nov 2015,14 Nov 2016
Weill Cornell Medical College New York United States
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Owing to its ability to spread systematically, breast cancer remains a life-threatening tumor. Therefore, efforts in developing new treatment strategies are needed in order to eradicate metastatic breast cancer. In this respect, the activation of the immune system to elicit anti-tumor immune responses represents one of the most promising approaches that have recently demonstrated some success in other diseases. However, clinically apparent tumors have already harnessed host mechanisms to prevent immune activation and to induce an immunosuppressive microenvironment hindering immunotherapy-based treatments. As a consequence, the immune system fails to recognize cancer cells as dangerous and actively suppresses anti-tumor immune responses.
- Medicine and Medical Research