BioProgrammable One, Two, and Three Dimensional Materials
Technical Report,15 Sep 2011,14 Sep 2016
Northwestern University Evanston United States
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The MURI team has used biomolecules such as DNA or peptides to assemble nanoparticles into highly ordered one-, two-, or three dimensional architectures. The Mirkin group has used DNA-functionalized nanoparticles as programmable atom equivalents PAEs as material synthons to synthesize hundreds of different crystal structures. The Macfarlane group developed methods to combine bottom-up DNA directed assembly with electron beam lithography to simultaneously control material structure at the nano- and macroscopic length scales. The Nguyen group has synthesized and assembled small molecule-DNA hybrids SMDHs as part of programmable atom equivalents. The Rosi group identified design rules for using peptide constructs to direct rational assembly of inorganic nanoparticles into ordered hierarchical nanoparticle superstructures, including hollow spherical structures and 1-D helical nanoparticle arrays exhibiting strong plasmonic chiroptical response. Theoretical studies as well as various characterization techniques were studied in conjunction with all of the abovementioned experimental approaches to construct new materials with biomolecule-functionalized building blocks. The Schatz group developed electrodynamics models of plasmonic superlattices to identify unique optical behavior of these materials, including negative permittivity, Fabry-Perot resonances, and nonreciprocal properties. The Olvera group predicted the shape of single crystals of DNA functionalized nanoparticles and their nucleation behavior. The Bedzyk group utilized in-situ X-ray scattering and spectroscopy to develop fundamental understanding of PAE constructs, from their synthesis and electrostatic environment, to inter-PAE interactions that affect programmable assembly. As a whole, the MURI team synthesized, measured, and evaluated a set of new materials with specific properties by design.
- Biomedical Instrumentation and Bioengineering