A Novel Animal Model for Investigating the Neural Basis of Focal Dystonia
Technical Report,01 Sep 2015,31 Aug 2016
The Research Foundation of State University Stony Brook
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The overall goal of the project was to develop an animal model of the focal dystonia benign essential blepharospasm. Consistent with the widely held view that dystonia results from an interaction between a predisposing condition and an environmental trigger, we proposed to use7 Hz deep brain stimulation of the basal ganglia as the predisposing condition and dry eye as an environmental trigger. Based on experiments during the 1st year of the grant, our publication, Evinger, J. Neuro-Ophthalmol. 35374-379, 2015 demonstrated the feasibility of this approach. In addition, we began important control experiments and preliminary recordings from the superior colliculus.
- Medicine and Medical Research
- Anatomy and Physiology