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Accession Number:
AD1029641
Title:
Molecular Profiling of Intraductal Carcinoma of the Prostate
Descriptive Note:
Technical Report,30 Sep 2013,29 Sep 2016
Corporate Author:
Johns Hopkins University Baltimore United States
Report Date:
2016-12-01
Pagination or Media Count:
43.0
Abstract:
Defined by the presence of malignant cells spreading within intact prostatic ducts and acini, intraductal carcinoma of the prostate IDC-P occurs almost exclusively in high Gleason grade and stage tumors and is a consistent independent risk factor for tumor progression and death. Importantly, however, IDC-P is currently systematically under-diagnosed in needle biopsies because it has significant morphologic overlap with another intraepithelial lesion, high grade prostatic intraepithelial neoplasia HGPIN. We hypothesize that IDC-P represents progression of invasive high-risk prostate carcinoma, and thus is molecularly distinct from HGPIN. Herein, we have conducted an unbiased, three-pronged set of experiments to definitively identify the molecular signature of IDC-P using a combination of protein, RNA, and DNA-based assays.
Distribution Statement:
APPROVED FOR PUBLIC RELEASE