Accession Number:

AD1029143

Title:

Novel Approaches to Breast Cancer Prevention and Inhibition of Metastases

Descriptive Note:

Technical Report,30 Sep 2015,29 Sep 2016

Corporate Author:

IMBA Institut fuer Molekulare Biotechnologie GmbH Vienna Austria

Personal Author(s):

• Penninger,Josef

Report Date:

2016-10-01

Pagination or Media Count:

39.0

Abstract:

Technologies such as transcriptional profiling, genome sequencing, epigenetic, proteomic or metabolomic profiling have resulted in large sets of genome wide data. However, most of these datasets are of correlative. Functional and phenotypic annotation of the genome is thus a key challenge for a fundamental understanding of physiology and disease pathogenesis. We combine genetic model organisms and repairable mutagenesis with in vivo mouse genetics and human cohort studies to functionally characterize candidate breast cancer genes. Using mouse genetics, we showed that RANKL and its receptor RANK are critical regulators of sex hormone and BRCA1 mutation-driven breast cancer, providing a rationale for cancer prevention trials.

Descriptors:

• breast cancer
• genetics
• angiogenesis
• genome
• therapeutics
• genetics
• biological markers
• neoplasms
• stem cells
• medical research

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE