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Novel Autoantibody Serum and Cerebrospinal Fluid Biomarkers in Veterans with Gulf War Illness
Technical Report,30 Sep 2015,29 Sep 2016
Duke University Medical Center Durham United States
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The purpose of this project is to develop objective peripheral biomarkers for Gulf War Illness GWI. We plan to determine circulating autoantibodies to ten proteins associated with the central nervous system in sera and plasma from a group of 250 Gulf War veterans with Gulf War Illness GWI and from 200 controls 100 healthy GW controls, 100 disease controls. Preliminary results using Western blot assay showed increased levels of autoantibodies in GWI cases compared to symptomatic controls in the following descending order CaMKII GFAP Tau Tubulin MAG MAP-2 MBP NFP S100B ranging from 2-8 fold higher. These results confirm the continuing presence of autoantibodies against neuronal gliosis in these veterans and are in agreement with recent reports indicating that 25 years after the war, the health of veterans with GWI is not improving and maybe getting worse. Such blood-based autoantibodies may prove useful as biomarkers of GWI, upon validation of the findings using larger cohorts.
APPROVED FOR PUBLIC RELEASE