Accession Number:

AD1028574

Title:

A New Tool for Local Manipulation of Neuronal Micro-Circuitry with Ions and Force

Descriptive Note:

Technical Report,30 Jul 2015,30 Sep 2016

Corporate Author:

Regents of the University of California Santa Barbara United States

Personal Author(s):

• Kosik,Kenneth S.

Report Date:

2017-02-07

Pagination or Media Count:

5.0

Abstract:

Our goal is to compute the complete functional connectivity map of a living neuronal network spontaneously assembled in culture and determine the utility of its information content as a synthetic memory trace. To date no functional connectivity map exists for living neurons at the resolution proposed here. In fact, a quantitative model of the microcircuitry at the level of the single synapse remains inaccessible with current technology. We will develop a deep learning module for diagnosing MEA patterns and establish a complete connectivity map for hippocampal cultured neurons.

Descriptors:

• NEURONS
• electrodes
• microscopy
• nervous system

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE