Aldehyde Recognition and Discrimination by Mammalian Odorant Receptors via Functional Group-Specific Hydration Chemistry
CUNY - City College of New York New York United States
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The mammalian odorant receptors ORs form a chemical-detecting interface between the atmosphere and the nervous system. This large gene family is composed of hundreds of membrane proteins predicted to form as many unique small molecule binding niches within their G-protein coupled receptor GPCR framework, but very little is known about the molecular recognition strategies they use to bind and discriminate between small molecule odorants.