Accession Number:

AD1028493

Title:

Aldehyde Recognition and Discrimination by Mammalian Odorant Receptors via Functional Group-Specific Hydration Chemistry

Descriptive Note:

Journal Article

Corporate Author:

CUNY - City College of New York New York United States

Personal Author(s):

• Li,Yadi
• Peterlin,Zita
• Ho,Jianghai
• Yarnitzky,Tali
• Liu,Min T.
• Fichman,Merav
• Niv,Masha Y.
• Matsunami,Hiroaki
• Firestein,Stuart
• Ryan,Kevin

Report Date:

2015-09-02

Pagination or Media Count:

12.0

Abstract:

The mammalian odorant receptors ORs form a chemical-detecting interface between the atmosphere and the nervous system. This large gene family is composed of hundreds of membrane proteins predicted to form as many unique small molecule binding niches within their G-protein coupled receptor GPCR framework, but very little is known about the molecular recognition strategies they use to bind and discriminate between small molecule odorants.

Descriptors:

• aldehydes
• fluorescence
• molecular biology
• cell physiological processes
• membrane proteins
• hydrogen bonds
• fluorine
• biological products
• proteins
• luminescence
• computational modeling
• fluorescent dyes

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE