Temporal Changes in FLT3 ITD Regulation of Stem Cell Self Renewal and Leukemogenesis
Technical Report,01 Sep 2014,31 Aug 2016
Washington University ST. Louis United States
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My goal is to understand how mechanisms that regulate normal hematopoietic development can also influence the mutation spectra of pediatric and adult acute myeloid leukemia AML. Genetic differences between pediatric and adult AML may underlie differences in outcomes and necessitate different treatment strategies, yet we have few insights into why these differences occur. To address this problem, we are testing whether one mutation, FLT3-ITD, differentially regulates fetal and adult progenitors.