Accession Number:

AD1028492

Title:

Temporal Changes in FLT3 ITD Regulation of Stem Cell Self Renewal and Leukemogenesis

Descriptive Note:

Technical Report,01 Sep 2014,31 Aug 2016

Corporate Author:

Washington University ST. Louis United States

Personal Author(s):

Report Date:

2016-11-01

Pagination or Media Count:

76.0

Abstract:

My goal is to understand how mechanisms that regulate normal hematopoietic development can also influence the mutation spectra of pediatric and adult acute myeloid leukemia AML. Genetic differences between pediatric and adult AML may underlie differences in outcomes and necessitate different treatment strategies, yet we have few insights into why these differences occur. To address this problem, we are testing whether one mutation, FLT3-ITD, differentially regulates fetal and adult progenitors.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE