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Citrullinated Chemokines in Rheumatoid Arthritis
Technical Report,30 Sep 2013,29 Sep 2016
Regents of the University of Michigan Ann Arbor United States
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Citrullination, catalysed by peptidylarginine deiminase PAD, is a post-translational modification of arginine to citrulline, which contributes to the pathogenesis of rheumatoid arthritis RA. We show that citrullinated epithelial-derived neutrophil-activating peptide78CXCL5 cit-ENA-78CXCL5 is significantly higher in RA synovial fluids SFs compared to osteoarthritis OA and other inflammatory rheumatic diseases OD SFs, and its concentration correlates with RA disease activity. Citrullinated chemokine concentrations were measured by enzyme linked immunosorbent assay ELISA in RA and normal NL sera and in RA, osteoarthritisOA, and other inflammatory rheumatic disease OD synovial fluids SFs. The correlation between the citrullinated chemokine levels and clinical data was analyzed. A strong correlation was found between the amounts of citENA-78CXCL5 and C-reactive protein orerythrocyte sedimentation rate ESR in RA SFs. These results indicate that citENA-78CXCL5 may have novel inflammatory properties inRA pathogenesis.
APPROVED FOR PUBLIC RELEASE