Accession Number:

AD1028459

Title:

Antimicrobial Silk Ocular Drug Delivery Implant for Chronic Posterior Segment Diseases

Descriptive Note:

Technical Report,15 May 2015,14 May 2016

Corporate Author:

Tufts University Medford United States

Personal Author(s):

• Kaplan,David L
• Behlau,Irmgard

Report Date:

2016-06-01

Pagination or Media Count:

11.0

Abstract:

An intreocular insert based on fibroin was designed and optimized. The insert contains a hollow channel that was preloaded with the anti-VEGF antibody bevacizumab. The device was covalently coated with the antibacterial polymer HMPE1 to protect against biofilm formation and the transmission of harmful bacterial to the interior of the ocular chamber.

Descriptors:

• silk
• diabetes
• eye
• surgical transplantation
• eye diseases
• therapy

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE