Accession Number:

AD1028451

Title:

Targeting Common but Complex Proteoglycans on Breast Cancer Cells and Stem Cells Using Evolutionary Refined Malaria Proteins

Descriptive Note:

Technical Report,15 Jul 2015,14 Jul 2016

Corporate Author:

The University of British Columbia Vancouver Canada

Personal Author(s):

• Daugaard,Mads

Report Date:

2016-08-01

Pagination or Media Count:

77.0

Abstract:

In the past year of the project we have successfully produced recombinant VAR2CSA that binds with high affinity and high specificity to breast cancer cells and breast cancer tissue biopsies. We have demonstrated that the protein binds to distinct secondary modified proteoglycans exclusively present on breast cancer cells and that targeting these with recombinant VAR2CSA interferes with key functions of the cancer cell like growth, migration and invasion.

Descriptors:

• breast cancer
• MALARIA
• proteins
• cell physiological processes
• confocal microscopy
• surface plasmon resonance
• cell membrane
• polysaccharides
• embryonic structures
• epithelial cells
• mass spectrometry
• neoplasms
• tissues (biology)

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE