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Targeting Sulfotransferase (SULT) 2B1b as a Regulator of Cholesterol Metabolism in Prostate Cancer
Technical Report,30 Sep 2014,29 Sep 2015
Purdue University West Lafayette United States
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Abundant epidemiological and experimental evidence establishes alterations in cholesterol metabolism as a key driver of prostate cancer PCa aggressiveness. Our preliminary data shows cholesterol sulfotransferase SULT 2B1b, a global regulator of cholesterol metabolism, is overexpressed in human prostate neoplasia and PCa cell lines and that genetic knock down suppresses LNCaP growth and diminishes androgen receptor AR activity. It is hypothesized that SULT2B1b modulates PCa growth and phenotype via alterations in cholesterol metabolism. If validated, the studies will form the foundation for novel therapeutic intervention.
APPROVED FOR PUBLIC RELEASE