Accession Number:

AD1028428

Title:

Targeting Sulfotransferase (SULT) 2B1b as a Regulator of Cholesterol Metabolism in Prostate Cancer

Descriptive Note:

Technical Report,30 Sep 2014,29 Sep 2015

Corporate Author:

Purdue University West Lafayette United States

Personal Author(s):

• Ratliff,Timothy

Report Date:

2015-10-01

Pagination or Media Count:

15.0

Abstract:

Abundant epidemiological and experimental evidence establishes alterations in cholesterol metabolism as a key driver of prostate cancer PCa aggressiveness. Our preliminary data shows cholesterol sulfotransferase SULT 2B1b, a global regulator of cholesterol metabolism, is overexpressed in human prostate neoplasia and PCa cell lines and that genetic knock down suppresses LNCaP growth and diminishes androgen receptor AR activity. It is hypothesized that SULT2B1b modulates PCa growth and phenotype via alterations in cholesterol metabolism. If validated, the studies will form the foundation for novel therapeutic intervention.

Descriptors:

• cholesterol
• prostate cancer
• metabolism
• neoplasms
• cells(biology)
• receptors(physiology)
• androgens
• therapy
• medical research
• apoptosis

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE