Role of Snf5 Mutations in Schwannomatosis Pain
Technical Report,30 Sep 2015,29 Sep 2016
OREGON HEALTH AND SCIENCE UNIV BEAVERTON BEAVERTON United States
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The overarching goal of this proposal is to test the hypothesis that Snf5 gene also calledSMARCB1 mutations that occur in schwannomatosis patients contribute to the unique, untreatable pain experienced by these patients. During the first year of this project, we found that mice with Schwann cell-targeted Snf5 mutations demonstrated increased TRPV1 and CGRP expression, two factors linked to pain phenotype, expression in both large and small diameter sensory neurons and were typically co-expressed by these cells. We have also completed a proteomic screen of Snf5-mutant Schwann cell conditioned medium and identified several factors that may contribute to schwannomatosis pain phenotypes.