Accession Number:

AD1028092

Title:

Adaptive Control of Bivalirudin in the Cardiac Intensive Care Unit

Descriptive Note:

JOURNAL ARTICLE - OPEN ACCESS

Corporate Author:

University of Texas at Austin Austin United States

Personal Author(s):

• Edrich,Thomas
• Zhao,Qi
• Paschalidis,Ioannis Ch.

Report Date:

2015-01-01

Pagination or Media Count:

13.0

Abstract:

Bivalirudin is a direct thrombin inhibitor used in the cardiac intensive care unit when heparin is contraindicated due to heparin-induced thrombocytopenia. Since it is not a commonly used drug, clinical experience with its dosing is sparse. In earlier work 1 we developed a dynamic system model that accurately predicts the effect of bivalirudin given dosage over time and pa- tient physiological characteristics. This paper develops adaptive dosage controllers that regulate its effect to desired levels. To that end, and in the case that bivalirudin model parameters are available,we develop a Model Reference Control law. In the case that model parameters are unknown, an indirect Model Reference Adaptive Control scheme is applied to estimate model parameters first and then adapt the controller. Alternatively, direct Model Reference Adaptive Control is applied to adapt the controller directly without estimating model parameters first. Our algorithms are validated using actual patient data from a large hospital in the Boston area.

Descriptors:

• inhibitors
• pharmacokinetics
• blood coagulation
• algorithms
• adaptive control systems
• thrombocytopenia
• drugs
• dosage
• cardiac care units
• medical research

Subject Categories:

• Medicine and Medical Research
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE