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The Roles of the Bone Marrow Microenvironment in Controlling Tumor Dormancy

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Technical Report,08 Sep 2015,07 Sep 2016

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Wake Forest University Health Sciences Winstson-Salem United States

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The purpose of this study is to identify the mechanisms whereby the bone marrow microenvironment is involved in regulation of tumor dormancy. Aim1 will identify and explore how disseminated tumor cells DTCs stay dormant for long periods of time. We postulate that DTCs drive the bone marrow niche into dormancy through the GAS6 pathway. Aim2 will determine how DTCs escape dormancy, consequently rendering them more susceptible to the chemotherapy. As a major accomplishment of this study during this period is that the PI, Dr. Yusuke Shiozawa, accepted a position as an Assistant Professor at Wake Forest School of Medicine as of 030115, and as of 070116, a transfer of the award from the University of Michigan to Wake Forest School of Medicine was completed. We developed an innovative and powerful mouse models that enable us to measure within the same animal i the growth of bone metastatic prostate cancer and ii bone remodeling. This newly established mouse model allow us to evaluate the interaction between the bone marrow niche and disseminated prostate cancer cells.

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  • Medicine and Medical Research

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