Effect of Prazosin and Naltrexone on Script Induced Alcohol Craving in Veterans with Alcohol Use Disorders with and without Co-occurring PTSD
Technical Report,04 Dec 2015,03 Dec 2016
Seattle Institute for Biomedical and Clinical Research Seattle United States
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Background Military personnel are at risk for developing hazardous drinking patterns post-deployment that can negatively impact their health and psychiatric stability. This phenomenon is compounded by the fact that despite recent gains in establishing effective pharmacological and behavioral treatments for alcohol use disorders AUD, nonremittance and relapse remain major problems for those with AUDs. One individual factor that is strongly associated with continued problematic use and relapse is craving. Three different types of craving have been hypothesized, reward, relief, and obsessive, and each is postulated to be mediated by different neurological substrates. The neural networks postulated to subserve reward and relief craving receive afferents from and project to noradrenergic neurons in non-human primates and humans express alpha1 adrenergic receptors. Given the interplay of the noradrenergic system with craving-related brain systems, blocking alpha1 receptors with the noradrenergic antagonist, prazosin, theoretically has the potential to modulate reward and relief craving.
- Medicine and Medical Research