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The Impact of Ethnicity-Dependent Differences in Breast Epithelial Hierarchy on Tumor Incidence and Characteristics

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Technical Report,30 Sep 2015,29 Sep 2016

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Trustees of Indiana University Indianapolis United States

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The incidence of young-onset and the most aggressive triple negative breast cancer TNBC is significantly higher in African American than Caucasian women suggesting that the biology of normal breast epithelial cells between these two ethnic groups differ, which may contribute to altered susceptibility to tumor initiation, progression andor metastasis. To address this hypothesis, we have generated immortalized cell lines from healthy breast tissues of African American and Caucasian women and transformed these cells with mutant p53, activated K-RAS,and PIK3CA. Unlike previous published studies, these transformed cells, particularly from Caucasian, displayed luminal progenitor phenotype. Transformed cells are being characterized for signal transduction pathway activation. Transformed cells from African American women showed aggressive phenotype with inherent plasticity and epithelial to mesenchymal transition like features. Xenograft studies are underway to determine whether these transformed cells show ethnicity-dependent differences in tumorigenecity and metastasis.

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  • Medicine and Medical Research

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