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Noninvasive Characterization of Indeterminate Pulmonary Nodules Detected on Chest High-Resolution Computed Tomography

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Technical Report,30 Sep 2015,26 Sep 2016

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Vanderbilt University Nashville United States

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Purpose Lung cancer is the most common cause of cancer-related deaths in the US. Results from the National Lung Screening Trial NLST, a large randomized controlled trial, suggest that screening with annual low-dose, high-resolution computed tomography of the chest HRCT reduces lung cancer specific mortality by 20 . The major challenge for the implementation of lung cancer screening is the high false positive rate. In the NLST, 40 of the participants in the HRCT were found to have lung nodules, 95 of which proved benign. This high false positive rate limits the applicability of this strategy at the population level, and could result in increased patient anxiety, radiation exposure, health care costs, and procedural morbidity and mortality. Our work aims at identifying HRCT-based and clinical variables to derive a model which will non-invasively distinguish benign from malignant nodules.

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