Accession Number:

AD1025966

Title:

Imaging Depression in Adults with ASD

Descriptive Note:

Technical Report,30 Sep 2015,29 Sep 2016

Corporate Author:

New York, State University of, Stony Brook Stony Brook United States

Personal Author(s):

Report Date:

2016-10-01

Pagination or Media Count:

21.0

Abstract:

Aim A To determine if the immunologic bias in autism spectrum disorder ASD confers greater risk for co-occurring depression than severity of ASD. If depression severity is associated with increased cytokine levels reported in non-ASD adults, this would support the notion that depression is a valid clinical syndrome within the ASD clinical phenotype, but not necessarily the same disorder as in neurotypical populations. Aim B To determine if depression symptoms are associated with clinical features similar to previous research about depression in neurotypical adults e.g., brain activation in response to social stress and correlation with cytokine levels and depression severity. If findings are consistent, this would support the notion that depression may be a true co-morbidity. Method Participants will be men NSO 18-45 years old with IQ BO and ASD diagnosis, no previous head trauma, no seizure or autoimmune disorder, and no current immunologic medication. Participants will be complete diagnostic and psychosocial assessments and a blood draw. A significant other will also complete emotion symptom measures.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE