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Diagnosis of Late Stage, Early Onset, Small Fiber Polyneuropathy

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Technical Report,30 Sep 2015,29 Sep 2016

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Massachusetts General Hospital Boston United States

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Our prior award generated evidence that some syndromes involving unexplained chronic multisymptom illness CMI and chronic widespread pain CWP, including Gulf War Illness GWI, may involve small-fiber polyneuropathy SFPN. Objective diagnostic measures suggest that some veterans with GWI may have longstanding, persistent early-onset SFPN. We are developing and evaluating generally applicable tools that can better screen and test Veterans with GWI for such long-standing, early-onset SFPN. These include simple screening tools such as targeted questionnaires and detection of abnormal sweating, pupil size and reactivity. Once diagnosed, we plan to develop and apply DNA sequencing panels to identify polymorphisms that may convey risk for developing SFPN. This project, which expands on our previous findings, is in collaboration with the Veterans Biomedical Research Institute at the East Orange NJ Veterans Administration Hospital. This report covers first year progress.

Subject Categories:

  • Medicine and Medical Research

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