Differential Splicing of Oncogenes and Tumor Suppressor Genes in African- and Caucasian-American Populations: Contributing Factor in Prostate Cancer Disparities
Technical Report,30 Sep 2015,29 Sep 2016
George Washington University School of Medicine Washington United States
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There are striking populationrace disparities in prostate cancer PCa risk and survival outcome borne out of current health statistics data. This is particularly evident between African AmericansAA and their European American EA counterparts. Epidemiologic studies have shown that higher mortality and recurrence rates for prostate cancer are still evident in AA men even after adjustment for socioeconomic status, environmental factors and health care access. Thus, it is likely that intrinsic biological differences account for some of the cancer disparities. Our overarching hypothesis is that the biological component of prostate cancer health disparities is due, in part, to population-dependent differential splicing of oncogenes and tumor suppressor genes in cancer specimens. The application of genomic approaches has identified splice variants in AA specimens, but absent in EA specimens, encoding more aggressive oncogenic proteins, thereby producing a more cancerous phenotype.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research