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Characterizing Treatable Causes of Small Fiber Polyneuropathy in Gulf War Veterans

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Technical Report,30 Sep 2015,29 Sep 2016

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Massachusetts General Hospital Boston United States

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Damage to the small nerve fibers that sense pain and regulate function of internal organs results in small-fiber polyneuropathy SFPN. SFPN symptoms include unexplained chronic widespread pain CWP and chronic multisymptom illness CMI similar to Gulf War Illness. Our prior research demonstrated that SFPN is prevalent in such CWP and CMI syndromes and that it can have onset at a young age. Given these non-specific symptoms, objective testing is recommended for SFPN diagnosis. In the second year of this study Global experts participated in early rounds of a Delphi method process to determine the most reliable markers for SFPN Case Definition via a secure Internet site developed in year one. We also completed a retrospective study to determine if common blood tests have utility in diagnosing SFPN because some causes are treatable. We published the results in which we identified blood tests with historically good predictive value.

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  • Medicine and Medical Research

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