A Highly Responsive Silicon Nanowire/Amplifier MOSFET Hybrid Biosensor
Yale University New Haven United States
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This study demonstrates a hybrid biosensor comprised of a silicon nanowire SiNW integrated with an amplifier MOSFET to improve the current response of field-effect-transistor FET-based biosensors. The hybrid biosensor is fabricated using conventional CMOS technology, which has the potential advantage of high density and low noise performance. The biosensor shows a current response of 5.74 decades per pH for pH detection, which is 2.5 105 times larger than that of a single SiNW sensor. In addition, we demonstrate charged polymer detection using the biosensor, with a high current change of 4.5 105 with a 500 nM concentration of polyallylamine hydrochloride.In addition, we demonstrate a wide dynamic range can be obtained by adjusting the liquid gate voltage. We expect that this biosensor will be advantageous and practical for biosensor applications which requires lower noise, high speed, and high density.
- Electrical and Electronic Equipment