Accession Number:

AD1025201

Title:

Utilization of ICU Data to Improve 30 and 60 Day Mortality Models

Descriptive Note:

Technical Report

Corporate Author:

APPLIED RESEARCH ASSOCIATES INC ARLINGTON VA ARLINGTON United States

Report Date:

2017-01-06

Pagination or Media Count:

39.0

Abstract:

This report presents the use of available ICU data to extend the capabilities of 30 and 60-day mortality models in the Health Effects from Nuclear and Radiological Environments HENRE software. These models relate levels of molecular and cellular biomarkers currently modeled in HENRE to mortality using data from the medical literature. A small intestine injury model predicts the probability of 30-day mortality after radiation and burn combined injuries using the biomarker citrulline, and a platelet reduction model predicts the probability of 60-day mortality after burn. These models have been developed to predict mortality of casualties with access to standard medical care. A review of the literature on the use of the neutrophil to lymphocyte ratio NLR as a biomarker of inflammation and mortality is presented. The NLR may be used in future work to further extend the capabilities of the mortality models in HENRE.

Subject Categories:

  • Radiobiology
  • Weapons Effects (Biological)

Distribution Statement:

APPROVED FOR PUBLIC RELEASE