Computational Fluid Dynamics Simulations of Inhaled Nano- and Micro-Particle Deposition in the Rhesus Monkey Nasal Passages
Technical Report,02 Oct 2011,01 Oct 2012
Applied Research Associates, Inc. Arlington United States
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Anatomically accurate computational fluid dynamics CFD models of the nasal passages of an infant 6 months old, 1.3 kg and adult 7 years old, 11.9 kg rhesus monkey were used to predict deposition of inhaled nano- and micro-particles. Steady-state, inspiratory airflow simulations were conducted in each model at flow rates equal to 100, 200, and 300 of the estimated minute volume for resting breathing. Particle transport and deposition simulations were conducted using the Lagrangian method to track the motion of individual particles that were passively released from the nostrils. Semi-empirical curves for nasal deposition were developed based on the simulation data for nano- and micro-particle deposition to allow for simplified calculations of age-based nasal deposition in the rhesus monkey nasal passages that can be implemented into lung dosimetry models.
- Medicine and Medical Research
- Anatomy and Physiology