Peptide Functionalized Gold Nanorods for the Sensitive Detection of a Cardiac Biomarker Using Plasmonic Paper Devices (Postprint)
Washington University in St. Louis St. Louis United States
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The sensitivity of localized surface plasmon resonance LSPR of metal nanostructures to adsorbates lends itself to a powerful class of label-free biosensors. LSPR properties are dependent on the geometrical features of the plasmonic nanostructures and the local dielectric environment. The exponential decay of the sensitivity from the surface of the plasmonic nanotransducer calls for the careful consideration in its design with a particular attention to the size of the recognition and analyte layers. In this study, we demonstrate that short peptides as biorecognition elements BRE compared to larger antibodies as target capture agents offer several advantages. The smaller sized peptide provides higher sensitivity and a lower detection limit using LSPR-based sensing. Furthermore, the excellent temporal and thermal stability of peptide-based LSPR sensors, which precludes the need for special storage conditions, makes it ideal for use in resource-limited settings.