Customized Fabrication of Osteochondral Tissue for Articular Joint Surface Repair
Technical Report,25 Aug 2015,24 Aug 2016
University of Pittsburgh Pittsburgh United States
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Osteoarthritis OA is a chronic degenerative disease of the articular joint that involves more than just the destruction of the articular cartilage it is a disease of the cartilage, bone and surrounding soft tissue that disables 9-10 of the US population. In the US military, combat and non-combat injuries experienced during deployments, training and generally active life-style can cause traumatic mechanical destruction or progressive biological degeneration of the articular cartilage. It has been reported that OA is the most frequent cause of disability in the armed forces. There are currently no effective therapies for OA. A regenerative surgical approach that aims for biological resurfacing of the joint is thus needed. In this study, we will construct adipose stem cell-laden scaffolds loaded with microparticles, designed to provide temporospatially specific differentiation cues for chondrogenesis and osteogenesis, by the 3D printing method of projection stereolithography PSL. We further test the applicability of these novel osteochondral tissues for articular cartilage repair in rabbit model, using medical imaging-guided PSL. Such an approach may be adapted for the development of a single-step, point-of-care procedure for clinical cartilage repair. If successful, the technology being developed here could accelerate the rate of recovery and therefore shorten the time away from active duty status and the duration of rehabilitation, while allowing full recovery of joint function and minimizing the impact on military medical care costs.
- Medicine and Medical Research