YY1 Control of AID-Dependent Lymphomagenesis
Technical Report,01 Jul 2014,30 Jun 2016
University of Pennsylvania Philadelphia United States
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We hypothesized that YY1 levels control AID nuclear accumulation, AID mutation rates, and subsequent AID-mediated B cell lymphomagenesis. We tested this hypothesis by exploring the impact of YY1 overexpression, ordeletion, in mouse lines that spontaneously develop AID-dependent B cell lymphoma. Our results suggest that overexpression of YY1 leads to higher mortality.