Accession Number:

AD1024757

Title:

YY1 Control of AID-Dependent Lymphomagenesis

Descriptive Note:

Technical Report,01 Jul 2014,30 Jun 2016

Corporate Author:

University of Pennsylvania Philadelphia United States

Personal Author(s):

Report Date:

2016-09-01

Pagination or Media Count:

35.0

Abstract:

We hypothesized that YY1 levels control AID nuclear accumulation, AID mutation rates, and subsequent AID-mediated B cell lymphomagenesis. We tested this hypothesis by exploring the impact of YY1 overexpression, ordeletion, in mouse lines that spontaneously develop AID-dependent B cell lymphoma. Our results suggest that overexpression of YY1 leads to higher mortality.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE