A Molecular Framework for Understanding DCIS
Technical Report,30 Sep 2015,29 Sep 2016
Duke University Durham United States
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DCIS is proposed to be a precursor to invasive breast cancer. Improvements in early diagnosis have led to increased numbers of DCIS cases, however, we presently have no way to predict which DCIS lesions are at risk for progression to invasive cancer. We also lack the extensive molecular profiling necessary to place DCIS within the framework used to classify and guide treatment for invasive disease. We propose to take advantage of a unique set of specimens, comprising DCIS and early invasive disease, and using next-generation sequencing, understand the nature of DCIS and the events that determine and promote its progression. We have already developed the approaches necessary for obtaining profiles from the tumor and stromal compartments of DCIS, lesions from which only limited numbers of cells can be obtained. The availability of our datasets will transform the understanding of early disease and may ultimately alter the course of treatment for women with a diagnosis of DCIS.
- Medicine and Medical Research
- Anatomy and Physiology