Studies of the Effects of Perfluorocarbon Emulsions on Platelet Number and Function in Models of Critical Battlefield Injury
Technical Report,15 Dec 2013,14 Dec 2014
Virginia Commonwealth University Richmond United States
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Perfluorocarbon emulsions PFCs can treat traumatic injuries traumatic brain injury TBI, hemorrhagic shock and burns by enhanced delivery of oxygen. A class-based side effect of PFC day 2-5 after infusion in 30-50 may be thrombocytopenia TCYP. The mechanism is inadequately investigated. The US Food and Drug Administration FDA requests investigation of the phenomenon to exclude platelet inflammatoryembolic safety risks. In phase one of the study, the results showed that the sheeps platelet number and activation were not significantly changed after PFC infusion. In 2014, PFC intravenous infusion as a part of resuscitation fluid was used in hemorrhagic sheep PFC oxygent, n6 saline n7 surgical control n6. The initial results showed that the sheeps platelet count and fibrinogen level were not significantly reduced after PFC infusion compared with non-PFC controls for the 7 survival days. Platelet contractile force PCF, Platelet activator also showed no significant reduction compared with control groups saline and surgical control. Platelet morphological observation corresponds with function assays. There are no significant percentage changes in neutrophils and monocytes after PFC infusion. Therefore, intravenous infusion of Oxygent PFC in hemorrhagic shock sheep did not cause massive or severe coagulopathy.
- Anatomy and Physiology
- Medicine and Medical Research