Accession Number:

AD1024723

Title:

Biological and Genomic Differences of ERG Oncoprotein-Stratified Prostate Cancers from African and Caucasian Americans

Descriptive Note:

Technical Report,30 Sep 2015,29 Sep 2016

Corporate Author:

Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Bethesda United States

Personal Author(s):

Report Date:

2016-10-01

Pagination or Media Count:

14.0

Abstract:

There is striking disparity in prostate cancer incidence and mortality for African American men as compared to Caucasian Americans. The objective of this proposal is to determine associations and racial differences in the distribution of key clinic-pathologic patient features and molecular determinants for both ERG positive and ERG negative prostate cancer. It is anticipated that molecular determinants of aggressive prostate cancer in African American men, including somatic mutations and SNPs associated with prostate cancer risk, may associate with ERG fusion negative prostate cancer.

Subject Categories:

  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE