Studies of the Effects of Perfluorocarbon Emulsions on Platelet Number and Function in Models of Critical Battlefield Injury
Technical Report,15 Dec 2014,14 Dec 2015
Virginia Commonwealth University Richmond United States
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Perfluorocarbon emulsions PFCs can treat traumatic injuries traumatic brain injury TBI, hemorrhagic shock and burns by enhanced delivery of oxygen. A class-based side effect of PFC day 2-5 after infusion in 30-50 may be thrombocytopenia TCYP. The mechanism is inadequately investigated. The US Food and Drug Administration FDArequests investigation of the phenomenon to exclude platelet inflammatoryembolic safety risks. The initial results phase I showed that PFC infusion in the normal sheep did not significantly change the platelet number and activation among the experimental and control groups. In 2015 Phase II and III, PFC infusion as a part of resuscitation fluid was used in sheep with hemorrhage n39 and polytrauma blast traumatic injury and hemorrhage, n8. The results showed that the sheeps platelet count and fibrinogen level were reduced immediately after resuscitation. However, there was no significant change of platelet number and activation after PFC infusion compared with non-PFC controls over the 7 survival days. Platelet contractile force PCF, Platelet activator also showed no significant change compared with control groups saline and surgical control. Platelet morphological observation corresponded well with function assays. There were no significant percentage changes in neutrophils and monocytes after PFC infusion in injured sheep.
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