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Microvesicle Production After Trauma and its Clinical Impact on Venothromboembolism

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Technical Report,01 Oct 2014,31 Dec 2015

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Mayo Clinic Rochester United States

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Polytrauma is most often caused from explosive devices and accounts for about 65 percent of injuries to our military personnel. The patients who have polytrauma are at increased risk of developing either bleeding andor a clot in their veins which cause a life-threatening event known as venous thromboembolism VTE. We began enrollment of patients into the study on 2 February 2011. As of 1 October 2012, we have successfully enrolled and collected blood samples on 684patients and 64 healthy volunteers. We have thus far analyzed plasma samples of over 230 patients and 64 volunteers. In our preliminary analysis of thrombin generation and procoagulant microvesicle analysis, we have observed that thrombin generation is accelerated early after traumatic injury and there are greater numbers of procoagulant microvesicles noted after traumatic injury relative to healthy volunteers.

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  • Medicine and Medical Research

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