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The SOS Response is Permitted in Escherichia coli Strains Deficient in the Expression of the mazEF Pathway

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Journal Article - Open Access

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Hebrew University of Jerusalem Edmond J Safra Campus Israel

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The Escherichia coli E. coli SOS response is the largest, most complex, and best characterized bacterial network induced by DNA damage. It is controlled by a complex network involving the RecA and LexA proteins. We have previously shown that the SOS response to DNA damage is inhibited by various elements involved in the expression of the E. coli toxin-antitoxin mazEF pathway. Since the mazEF module is present on the chromosomes of most E.coli strains, here we asked Why is the SOS response found in so many E. coli strains Is the mazEF module present but inactive in those strains We examined three E. coli strains used for studies of the SOS response, strains AB1932,BW25113, and MG1655. We found that each of these strains is either missing or inhibiting one of several elements involved in the expression of the mazEF-mediated death pathway. Thus, the SOS response only takes place in E. coli cells in which one or more elements of the E. coli toxin-antitoxin module mazEF or its downstream pathway is not functioning.

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  • Medicine and Medical Research

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