Early Identification of Molecular Predictors of Heterotopic Ossification Following Extremity Blast Injury with a Biomarker Assay
Technical Report,30 Sep 2015,29 Sep 2016
Medical University of South Carolina Charleston United States
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The purpose of this project is to identify predictive markers of heterotopic ossification in an established animal model that would forecast development of heterotopic ossificationHO in humans soon after injury. Blast procedures have been completed on all 30 animalsGroups I and II in the year 1 SOW and 45 animals Groups III V in the year 2 SOW. All animals were biopsied and have been sacrificed according to protocol schedule. Groups I and II animals were also followed with scheduled routine radiographs to monitor progression of HO. Specimen samples are under analysis for gene and protein level expression with the Nesti partnering molecular biology lab. In the upcoming year, early-appearing gene and protein biomarkers will be identified by analyzing correlation in animals exhibiting radiographic evidence of HO and will be compared to gene expression signatures in existing human tissue samples known to have gone on to develop HO by the partnering lab.
- Medicine and Medical Research