Accession Number:

AD1024106

Title:

Stress and PTSD Mechanisms as Targets for Pharmacotherapy of Alcohol Abuse, Addiction and Relapse

Descriptive Note:

Technical Report,30 Sep 2015,29 Sep 2016

Corporate Author:

Seattle Institute for Biomedical and Clinical Research Seattle United States

Personal Author(s):

• Rasmussen,Dennis

Report Date:

2016-10-01

Pagination or Media Count:

30.0

Abstract:

We have demonstrated that 1 alcohol-nave rats exhibiting high acoustic startle response which is sequent associated with increased anxiety-like behavior develop increased subsequent alcohol intake and preference which are highly correlated with acoustic startle amplitude determined before the initial access to alcohol, providing a prospective index of vulnerability to developing alcohol abuse, as well as insights into mechanism.

Descriptors:

• TRAUMATIC STRESS DISORDER
• ANXIETY DISORDERS
• PREVENTIVE MEDICINE
• THERAPY
• ALCOHOLIC BEVERAGES
• ethanols
• drug abuse
• receptor sites (physiology)
• physiological effects
• response (biology)

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE