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Stress and PTSD Mechanisms as Targets for Pharmacotherapy of Alcohol Abuse, Addiction and Relapse
Technical Report,30 Sep 2015,29 Sep 2016
Seattle Institute for Biomedical and Clinical Research Seattle United States
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We have demonstrated that 1 alcohol-nave rats exhibiting high acoustic startle response which is sequent associated with increased anxiety-like behavior develop increased subsequent alcohol intake and preference which are highly correlated with acoustic startle amplitude determined before the initial access to alcohol, providing a prospective index of vulnerability to developing alcohol abuse, as well as insights into mechanism.
APPROVED FOR PUBLIC RELEASE