Accession Number:

AD1023997

Title:

A Multiplex Cancer/Testis Antigen-Based Biomarker Panel to Predict the Aggressive Phenotype of Prostate Cancer

Descriptive Note:

Technical Report,30 Sep 2012,29 Jun 2016

Corporate Author:

Johns Hopkins University Baltimore United States

Personal Author(s):

• Veltri,Robert W.

Report Date:

2016-09-01

Pagination or Media Count:

32.0

Abstract:

The CancerTestis Antigens CTAs are a group of proteins normally confined to germ cells but aberrantly expressed in several cancers. The central hypothesis of this grant application is that a CTA-based biomarker can be used to discern LPCa from MPCa. In the first year of this grant, we determined gene expression of 22 candidate CTAs by Nanostring and validated by qRT-PCR. During the second year of the grant, we used ROC curve analysis and identified 8 CTA genes CEP55, NUF2,PAGE4, PBK, RQCD1, SPAG4, SSX2 and TTK, which expression pattern is significant different between aggressive and indolent tumors.

Descriptors:

• prostate cancer
• metastasis
• gene expression
• neoplasms
• biological markers
• cancer research

Subject Categories:

• Genetic Engineering and Molecular Biology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE