A Multiplex Cancer/Testis Antigen-Based Biomarker Panel to Predict the Aggressive Phenotype of Prostate Cancer
Technical Report,30 Sep 2012,29 Jun 2016
Johns Hopkins University Baltimore United States
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The CancerTestis Antigens CTAs are a group of proteins normally confined to germ cells but aberrantly expressed in several cancers. The central hypothesis of this grant application is that a CTA-based biomarker can be used to discern LPCa from MPCa. In the first year of this grant, we determined gene expression of 22 candidate CTAs by Nanostring and validated by qRT-PCR. During the second year of the grant, we used ROC curve analysis and identified 8 CTA genes CEP55, NUF2,PAGE4, PBK, RQCD1, SPAG4, SSX2 and TTK, which expression pattern is significant different between aggressive and indolent tumors.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research