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Identifying Subgroups of Tinnitus Using Novel Resting State fMRI Biomarkers and Cluster Analysis

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Technical Report,15 Sep 2015,14 Sep 2016

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University of Illinois Urbana United States

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The subject of the project is FY14 PRMRP Topic Area - Tinnitus. The broad goal of this project is to link behavioral measures of tinnitus severity to brain imaging scans that target areas of auditory, attention, and emotion processing, which are important to the underlying neural mechanisms of tinnitus. This study uses functional magnetic resonance imaging fMRI and is taking place at the University of Illinois at Urbana-Champaign UIUC for civilian data collection patient and control and at Wilford Hall Ambulatory Surgical Center WHASC for military data collection patient and control. Identical audiological, behavioral, and brain imaging protocols are being used at both sites and include patients with a range of tinnitus severity. In Year 1, we have begun to use resting-state fMRI to identify measurable characteristics of functional connectivity in attention, emotion, and auditory processing networks that are exclusive to the tinnitus population. In Year 2, we will use clustering algorithms applied to the resting-state data to identify tinnitus subgroups within the patient population and pair them with specific behavioral characteristics.

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