Heterotopic Ossification Following Extremity Blast Amputation: An Animal Model in the Sprague Dawley Rat
Technical Report,30 Sep 2010,31 Dec 2015
Medical University of South Carolina Charleston United States
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Prior phase I protocols demonstrated water and the hind limb as the preferred medium and location in the animal model. Phase II demonstrated increased tissue damage from pulsed lavage, and a beneficial effect from amputation above the zone of blast injury. Phase III was designed to investigate effects of nonsteroidal anti-inflammatory NSAID medication and external beam radiation on development of HO prior studies served as the control group in order to limit animal numbers.
- Medicine and Medical Research
- Weapons Effects (Biological)