Accession Number:
AD1023944
Title:
Heterotopic Ossification Following Extremity Blast Amputation: An Animal Model in the Sprague Dawley Rat
Descriptive Note:
Technical Report,30 Sep 2010,31 Dec 2015
Corporate Author:
Medical University of South Carolina Charleston United States
Personal Author(s):
Report Date:
2016-03-01
Pagination or Media Count:
55.0
Abstract:
Prior phase I protocols demonstrated water and the hind limb as the preferred medium and location in the animal model. Phase II demonstrated increased tissue damage from pulsed lavage, and a beneficial effect from amputation above the zone of blast injury. Phase III was designed to investigate effects of nonsteroidal anti-inflammatory NSAID medication and external beam radiation on development of HO prior studies served as the control group in order to limit animal numbers.
Descriptors:
Subject Categories:
- Medicine and Medical Research
- Weapons Effects (Biological)