Accession Number:

AD1023944

Title:

Heterotopic Ossification Following Extremity Blast Amputation: An Animal Model in the Sprague Dawley Rat

Descriptive Note:

Technical Report,30 Sep 2010,31 Dec 2015

Corporate Author:

Medical University of South Carolina Charleston United States

Personal Author(s):

Report Date:

2016-03-01

Pagination or Media Count:

55.0

Abstract:

Prior phase I protocols demonstrated water and the hind limb as the preferred medium and location in the animal model. Phase II demonstrated increased tissue damage from pulsed lavage, and a beneficial effect from amputation above the zone of blast injury. Phase III was designed to investigate effects of nonsteroidal anti-inflammatory NSAID medication and external beam radiation on development of HO prior studies served as the control group in order to limit animal numbers.

Subject Categories:

  • Medicine and Medical Research
  • Weapons Effects (Biological)

Distribution Statement:

APPROVED FOR PUBLIC RELEASE