Genetic Modifiers of Ovarian Cancer
Technical Report,15 May 2010,14 May 2014
Mayo Clinic Rochester United States
Pagination or Media Count:
Individuals with germline mutations in BRCA1 have an elevated but incomplete risk of developing ovarian cancer suggesting the presence of genetic modifiers of ovarian cancer in this population. A genome wide association study GWAS for ovarian cancer in BRCA1 mutation carriers has identified several novel modifiers of ovarian cancer risk for BRCA1 mutation carriers that can be used for individualized ovarian cancer risk assessment.