Cytoprotection: Immune and Matrix Modulation of Tissue Repair
Technical Report,15 Mar 2010,14 Mar 2013
Benaroya Research Institute at Virginia Mason Seattle United States
Pagination or Media Count:
Our overall goal was to create new therapies to regulate tissue reparative processes through the use of specific extracellular matrix ECM components, which play a significant role in regulating the inflammatory processes that follow injury, creating cytoprotective environments that promote healing. Focusing on aspects of tissue repair, we invented ECM scaffolds comprised of engineered proteoglycans and natural collagen, which emphasize enhancement of elasticity, strength, and cellular integration with the host. Subsequently, we refined our studies to address a key challenge to clinical application of this technology, the host inflammatory response. We have met the goals of our two multi-part aims to 1 identify novel cytoprotective mediators associated with regulatory lymphocytes and innate immune activation and 2 use cytoprotective ECM hydrogels to promote the development of function and host-integration of a novel skeletal muscle implant the myobridge, designed to replace native skeletal muscle lost to traumatic injury. We completed the project with the benefit of an approved no-cost extension.
- Medicine and Medical Research