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Cytoprotection: Immune and Matrix Modulation of Tissue Repair

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Technical Report,15 Mar 2011,14 Mar 2012

Corporate Author:

Benaroya Research Institute at Virginia Seattle United States

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We took on the challenge to create new therapies to regulate tissue reparative processes through the use of specific extracellular matrix ECM components, which play a significant role in regulating the inflammatory processes that follow injury, creating cytoprotective environments that promote healing. Focusing on aspects of tissue repair, we invented ECM scaffolds comprised of engineered proteoglycans and natural collagen, which emphasize enhancement of elasticity, strength, and cellular integration with the host. Subsequently, we refined our studies to address a key challenge to clinical application of this technology, the host inflammatory response. We have met the goals of our first multi-part aim to identify novel cytoprotective mediators associated with regulatory lymphocytes and innate immune activation. With an approved no-cost extension, we are continuing the work of the second aim by using cytoprotective ECM hydrogels to promote the development of function and host-integration of a novel skeletal muscle implant referred to as a myobridge designed to replace native skeletal muscle lost to traumatic injury.

Subject Categories:

  • Medicine and Medical Research

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