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Skeletal Muscle Regeneration in a Rat (Rattus norvegicus) Model with CorMatrix and Adipose Derived Stem Cells

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Technical Report

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60 MDG CIF Travis AFB United States

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Introduction Extracellular matrix ECM shows promise to regenerate skeletal muscle in patients with volumetric muscle loss. Methods A full thickness muscle defect was surgically in the medial head of the rat gastrocnemius muscle. ECM derived from porcine small intestine was used to repair the defect. Rats were sacrificed at 3, 6, and 10 months to evaluate muscle healing. Results No visible wound related complications, gait deficits, or pain were observed in animals post-operatively. At 3 and 6 months there was evidence of angiogenesis, but the matrix did not stimulate muscle regeneration across the large gap. There was no significant difference in force generation among groups at 10 months post operatively. Conclusion Results from histologic analyses, muscle morphometry, and functional testing, data seem to indicate that there is no difference among groups or time points and there is no evidence of muscle regeneration across the gap area in any group.

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  • Medicine and Medical Research

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