Novel Treatment for Patients with Traumatic Brain Injury (TBI)
Technical Report,01 Apr 2015,31 May 2016
University of Miami Coral Gables United States
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Systemic hypotension independently increases morbidity and mortality after traumatic brain injury. The goal of all treatments is avoid hypotension and maintain cerebral perfusion. If this cannot be achieved with fluids, pressers are required. Unfortunately, refractoriness and other adverse events are common with standard of care catecholamine pressers and there are no FDA-approved alternatives if refractoriness develops or severe adverse events occur during treatment of a brain injured patient. This project was designed to provide an alternative and thereby extend the existing capability of physicians to treat patients with life threatening brain injury.