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Nanoparticle Based Contrast Enhancement for Discriminating Indolent From Aggressive Prostate Cancer

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Technical Report,15 May 2015,14 May 2016

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Dartmouth College Hanover United States

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This program aims to develop a new imaging technique that will enable earlier detection of clinically relevant prostate cancer and help doctors to distinguish between aggressive cancers that need immediate therapy and more slowly growing indolent tumors that can be passively followed through watchful waiting or active surveillance management. Specifically, we aim to image metallic and polymer nanoparticles as they congregate within cancer regions of the prostate. We are using electrical property sensing devices that we have developed for imaging the prostate. We hypothesize that as nanoparticles congregate within the prostate the electrical properties of the prostate will change. For example, if metal nanoparticles are injected into a man and bind to prostate cancer cells, the high electrical conductivity of the metal particles will cause the overall conductivity of the prostate in the region of these nanoparticle to change. We have been developing electrical property sensing techniques to image the prostate and aim to use this approach to image nanoparticle concentrations within the prostate. This program is specifically investigating how sensitive electrical property sensing devices are to changes in concentration of these nanoparticles in both bench-top experiments and in in vivo animal experiments. We expect that by the end of this exploration we will have demonstrated that electrical property sensing technologies are able to detect different levels of nanoparticle congregation within a prostate cancer model and expect that we will be well-positioned to move to more rigorous animal model validation and human studies.

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